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. 2017 Sep 14;9:297. doi: 10.3389/fnagi.2017.00297

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Copyright © 2017 Beach, Huck, Zhu and Bozoki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RSN connectivity significantly correlated with HR response intercept and mean HR response within AD subjects. Associated ICs are presented in blue, clusters are red-yellow. Mean cluster beta-values, representing cluster–network connectivity strength for each subject, are plotted against HR responses (mild/moderate AD (mAD) green circles, sAD purple circles). (A) Top—plot of positive association between precuneus—posterior DMN component (pDMN, IC 1) and HR change intercept; bottom—visualization of the cluster. (B) Top—plots of positive and negative associations of precuneus–pDMN and vmPFC–ventral SN (vSN, IC 14) component, respectively, for mean HR change; bottom—visualization of clusters. Clusters visualized at p < 0.05, family-wise error (FWE). Coordinates are MNI space.