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. 2017 Sep 14;9:297. doi: 10.3389/fnagi.2017.00297

Table 2.

Connectivity between cluster-resting state networks or between networks significantly correlated with Pain Assessment in Advanced Dementia (PAINAD) score differences between healthy seniors (HS) and Alzheimer’s disease (AD) and heart rate (HR) changes within AD subjects.

IC # RSN Statistical connectivity contrast PFWE #Vox MNI coord. Hemi Cluster location
X Y Z
PAINAD slope
IC 2 MesTemp Interaction HS < AD 0.04 18 50 2 −32 R Temporal pole
Interaction HS < AD 0.04 12 −6 42 −8 L vmPFC
ICs 1 and 8 pDMN —vDMN Interaction HS > AD 0.03 - - - - - Between ICs
Mean PAINAD
ICs 4 and 6 aDMN —vSN Interaction HS < AD 0.03 - - - - - Between ICs
HR change intercept
IC 1 pDMN Pos HR 0.002 270 2 −66 36 R Precuneus
Mean HR change
IC 1 pDMN Pos HR 0.005 166 2 −66 32 R Precuneus
IC14 vSN2 Neg HR 0.021 58 −2 42 −16 L vACC/vmPFC

IC, independent component; RSN, resting state network; PFWE, p-value of cluster after family-wise error correction; #Vox, number of voxels within the cluster; MNI coordinate, cluster maximum in mm; Hemi, hemisphere (L, Left vs. R, Right); MesTemp, Mesial Temporal component; pDMN, posterior default mode network component; vSN2, #2 ventral salience network component; Interaction, continuous covariate interaction effect between groups; Neg/Pos HR, negative or positive statistical heart rate correlation with connectivity; vmPFC, ventromedial prefrontal cortex.