Table 3.
Differential expression of sRNA genes under industrially relevant stress conditions.
| Small RNA | Fold change per condition | Small RNA | Fold change per condition | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cold | Heat | Acid | Osmotic | Oxidative | Starvation | Cold | Heat | Acid | Osmotic | Oxidative | Starvation | ||
| LLMGnc_001 | 3.3 | 2.2 | LLMGnc_086 | 2.5 | −2.1 | ||||||||
| LLMGnc_002 | −3.0 | −2.2 | −5.8 | LLMGnc_087 | −3.5 | −3.4 | −15.7 | ||||||
| LLMGnc_005 | 3.2 | 2.7 | LLMGnc_088 | −2.3 | −5.3 | ||||||||
| LLMGnc_006 | 4.6 | 2.3 | −4.6 | LLMGnc_091 | −3.8 | −2.3 | |||||||
| LLMGnc_009 | −2.0 | −3.8 | LLMGnc_092 | −9.2 | |||||||||
| LLMGnc_010 | −4.0 | LLMGnc_093 | −2.2 | −2.0 | −6.1 | ||||||||
| LLMGnc_013 | 3.1 | 2.3 | 2.5 | 2.4 | LLMGnc_095 | −2.3 | |||||||
| LLMGnc_015 | 2.5 | −2.4 | 2.1 | LLMGnc_098 | −2.1 | ||||||||
| LLMGnc_016 | 2.3 | LLMGnc_099 | 3.7 | −4.7 | |||||||||
| LLMGnc_017 | −3.1 | −2.1 | LLMGnc_100 | 3.0 | −2.1 | ||||||||
| LLMGnc_018 | 2.6 | LLMGnc_102 | 2.3 | 2.0 | −2.9 | ||||||||
| LLMGnc_019 | 5.4 | 2.1 | 2.0 | 2.1 | −9.4 | 2.9 | LLMGnc_103 | −4.2 | |||||
| LLMGnc_022 | −5.1 | −7.5 | LLMGnc_106 | −2.1 | −2.7 | ||||||||
| LLMGnc_023 | 6.8 | 4.2 | 6.9 | LLMGnc_109 | −2.1 | −2.8 | |||||||
| LLMGnc_025 | −4.6 | −5.0 | −4.8 | −3.1 | −2.7 | −6.0 | LLMGnc_110 | −2.6 | −2.7 | −2.6 | |||
| LLMGnc_026 | 2.7 | 4.7 | LLMGnc_111 | −2.1 | |||||||||
| LLMGnc_027 | 2.1 | LLMGnc_112 | −2.1 | −2.3 | −2.2 | ||||||||
| LLMGnc_029 | 2.6 | LLMGnc_113 | −2.8 | ||||||||||
| LLMGnc_031 | 4.5 | −2.3 | −12.0 | LLMGnc_114 | −2.0 | −3.0 | −2.4 | −3.0 | |||||
| LLMGnc_032 | −2.5 | −4.6 | LLMGnc_115 | −2.7 | −2.5 | ||||||||
| LLMGnc_034 | 4.9 | 3.8 | 2.5 | 2.5 | 5.2 | LLMGnc_118 | −4.1 | −75.3 | |||||
| LLMGnc_035 | 2.2 | 2.2 | −2.3 | 2.8 | 3.3 | −2.6 | LLMGnc_119 | −3.7 | |||||
| LLMGnc_036 | −214 | LLMGnc_121 | 5.6 | ||||||||||
| LLMGnc_038 | 2.1 | 3.2 | 3.6 | LLMGnc_127 | −2.2 | ||||||||
| LLMGnc_039 | −2.3 | −2.5 | −4.1 | LLMGnc_128 | 6.4 | 3.4 | −6.0 | 3.3 | |||||
| LLMGnc_042 | −3.0 | LLMGnc_129 | −2.1 | ||||||||||
| LLMGnc_046 | −3.6 | −7.7 | LLMGnc_130 | 2.1 | −2.2 | ||||||||
| LLMGnc_047 | 5.6 | −2.6 | 7.2 | LLMGnc_131 | −10.2 | −4.7 | |||||||
| LLMGnc_048 | −2.6 | LLMGnc_132 | −3.3 | −9.0 | |||||||||
| LLMGnc_049 | 2.7 | 2.1 | 3.8 | LLMGnc_137 | 2.0 | ||||||||
| LLMGnc_055 | −2.3 | LLMGnc_138 | −2.5 | −3.3 | −4.5 | ||||||||
| LLMGnc_056 | 2.7 | 2.1 | LLMGnc_141 | 8.2 | 2.2 | 2.2 | |||||||
| LLMGnc_057 | −7.1 | −20.1 | LLMGnc_142 | −2.1 | −2.3 | −3.1 | |||||||
| LLMGnc_058 | −3.9 | −12.1 | LLMGnc_143 | −2.0 | −6.3 | −2.1 | −2.3 | ||||||
| LLMGnc_059 | −2.4 | LLMGnc_145 | −2.2 | −7.3 | |||||||||
| LLMGnc_060 | 2.6 | LLMGnc_147 | −2.9 | −3.4 | −2.3 | ||||||||
| LLMGnc_061 | −2.4 | −2.3 | −2.5 | −2.4 | LLMGnc_148 | −2.5 | −2.1 | −5.9 | −3.2 | ||||
| LLMGnc_062 | −3.1 | −15.6 | −4.1 | −4.9 | LLMGnc_149 | −2.8 | |||||||
| LLMGnc_064 | −6.3 | −3.8 | −7.9 | −8.5 | −6.0 | −8.8 | LLMGnc_150 | −4.4 | |||||
| LLMGnc_065 | −6.5 | −6.0 | −16.5 | −7.2 | −4.4 | −26.4 | LLMGnc_152 | 10.7 | |||||
| LLMGnc_066 | −2.0 | −2.2 | −20.0 | LLMGnc_153 | 6.0 | ||||||||
| LLMGnc_068 | −2.6 | LLMGnc_155 | −3.0 | 3.3 | −3.1 | ||||||||
| LLMGnc_069 | 2.9 | −2.0 | LLMGnc_157 | −2.1 | −4.3 | ||||||||
| LLMGnc_070 | 2.4 | 2.0 | LLMGnc_161 | 5.4 | −2.1 | ||||||||
| LLMGnc_072 | 4.4 | −3.8 | LLMGnc_162 | −2.1 | −2.2 | ||||||||
| LLMGnc_073 | −2.4 | −2.1 | −2.2 | −4.5 | −2.4 | −4.0 | LLMGnc_164 | 3.0 | 2.3 | −6.2 | |||
| LLMGnc_075 | 2.8 | −2.1 | 2.1 | −19.1 | LLMGnc_165 | 3.5 | 2.8 | 3.4 | 5.0 | 2.1 | 2.7 | ||
| LLMGnc_076 | 4.0 | −2.4 | LLMGnc_175 | −2.1 | −12.0 | −48.6 | |||||||
| LLMGnc_079 | 4.1 | −6.2 | −280 | −2.1 | −4.2 | LLMGnc_176 | 6.3 | ||||||
| LLMGnc_080 | 2.5 | 2.3 | LLMGnc_177 | 10.4 | 2.9 | ||||||||
| LLMGnc_081 | −2.4 | LLMGnc_178 | −2.2 | −4.7 | |||||||||
| LLMGnc_082 | 7.0 | −2.6 | LLMGnc_179 | 2.8 | |||||||||
| LLMGnc_083 | 3.4 | 2.5 | −2.6 | LLMGnc_180 | −3.1 | ||||||||
| LLMGnc_084 | 2.9 | 2.9 | LLMGnc_182 | 3.2 | −2.1 | 3.3 | −2.0 | ||||||
| LLMGnc_085 | −11 | −4.0 | LLMGnc_184 | −2.3 | −3.2 | −2.4 | −2.1 | ||||||
The 110 sRNA genes that are differentially expressed in at least one stress condition, with a cut-off fold change ≥ 2, p ≤ 0.05 and logCPM > 1 are indicated. Blue: upregulated, red: downregulated, color intensity is a measure of fold change. The names of the sRNAs are those that have been previously annotated in L. lactis MG1363, the plasmid-free derivative of L. lactis NCDO712 (van der Meulen et al., 2016).