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. 2017 Sep 14;8:647. doi: 10.3389/fphar.2017.00647

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Copyright © 2017 Zuo, Zuo, Zheng, Wang, Zhou, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell adhesion assay. Mφ was co-cultured with SMC for 15 min in presence (black bars) or absence (white bars) of LPS. LPS induced a significant increase in Mφ adhesion to SMC by approximately threefold compared to unstimulated cells (A). Mφ from PAR-2-deficient mice (Mφ^PAR-2-/-) significantly reduced LPS-induced adhesion (A). SMC from PAR-2-deficient mice (SMC^PAR-2-/-) induced a significant inhibitory effect on LPS-induced adhesion (B). Results are presented as fold change of adhesion relative to medium treatment. Data represent mean ± SD. ^∗P < 0.05.