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. 2017 Sep 14;8:647. doi: 10.3389/fphar.2017.00647

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Copyright © 2017 Zuo, Zuo, Zheng, Wang, Zhou, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Culture medium from SMC^PAR-2-/- reduced inflammatory responsiveness in Mφ. SMC from control mice and PAR-2-deficient mice (SMC^PAR-2-/-) were preincubated with LPS, subsequently cell-free culture supernatants from SMC or SMC^PAR-2-/- were transferred to untreated Mφ cultures. Relative quantitative PCR analysis revealed that culture medium from SMC^PAR-2-/- did not affect the expression of IFN-γ (A) and IL-6 (B) in Mϕ, induced a significant down-regulation of TNF-α (C) and MCP-1 (D) expression in Mφ. Data represent relative fold of mRNA expression as compared to the control group. Data represent mean ± SD. ^∗P < 0.05.