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. 2017 Sep 19;37(5):BSR20170798. doi: 10.1042/BSR20170798

Figure 1. miR-494 protected against liver I/R injury in SD rats.

Figure 1

SD rats (n=6 rats per group) were sham-operated or subjected to 60-min liver ischemia followed by 6-h reperfusion. HIRI rats were treated with agomir-miR-494 or agomir-NC. (A,B) Serum level of ALT and AST, LDH, and GLDH was determined using commercial kits. (C) Concentration of liver oxidative parameters MDA, TOA, and OSI. (D) Relative miR-494 level in liver samples from different groups was measured by qRT-PCR. miR-494 expression was normalized to U6. (E) HE staining of liver samples. Arrow indicates hepatocyte injury. (F) TUNEL staining of hepatocellular apoptosis. All experiments were performed in triplicate, and data were represented as mean ± S.D. *, P<0.05 and **, P<0.01 compared with sham surgery group.