Scheme 2. Scope of the palladium-catalyzed difluoromethylation of heteroaryl bromides. aReaction conditions: heteroaryl bromide (0.5 mmol), (SIPr)Ag(CF2H) 2 (0.65 mmol), Pd(dba)2 (5.0 mol%), DPEPhos (10 mol%) in 2.0 mL toluene at 80 °C for 6–12 h under an argon atmosphere; bisolated yields; cPd(dba)2 (10 mol%) and DPEPhos (20 mol%) are used; dreactions conducted with Pd(dba)2 (10 mol%) and DPEPhos (20 mol%) for 24 h.
