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. 2017 Sep 14;8:1157. doi: 10.3389/fimmu.2017.01157

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Copyright © 2017 Vergani, Korsunsky, Mazzarello, Ferrer, Chiorazzi and Bagnara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IGHV gene-specific detectability. (A) Relative detectability for all genes. For ease of comparison, the efficiencies were scaled to set the minimal median efficiency (corresponding to IGHV2-70) to 1. (B) The IGHV gene-specific detectability positively correlates with the IGHV gene frequency observed in unique sequences derived from naïve peripheral blood B cells (R² = 0.27, P < 0.001). (C) The average IGHV gene frequency observed in our dataset (n = 11) correlates with the average frequency observed in 34 samples from 6 different published datasets (R² = 0.93, P < 0.0001). (D) IGHV gene frequencies and intra-sample variability.