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. 2017 Mar 29;42(11):2152–2162. doi: 10.1038/npp.2017.35

Figure 2.

Figure 2

Resting-state functional connectivity (RSFC) after administration of 3, 4-methylenedioxymethamphetamine (MDMA>Placebo). (a) Changes in global RSFC after MDMA (p<0.05, uncorrected; right insula cluster circled in red is used as a seed ROI for all follow-up analyses). (b) Seed-to-voxel RSFC of right insula-anchored salience network in the placebo condition. (c) Seed-to-voxel RSFC of right insula-anchored salience network in the MDMA condition. (d) Changes in right insular seed-to voxel RSFC after MDMA. Increases in RSFC (a) and positive RSFC correlations (b, c) are shown in warm colors. Decreases in RSFC are shown in cool colors. All seed-to-voxel images (b–d) were cluster corrected at a threshold of p<0.05, FDR. FDR, false discovery rate.