ROI-to-ROI resting-state functional connectivity (RSFC) of salience network hubs after administration of 3, 4-methylenedioxymethamphetamine (MDMA>Placebo). Seed ROIs are indicated by bold font. Decreases in RSFC are shown in cool colors. All images were corrected for multiple comparisons at a threshold of p<0.05, FDR. AI, anterior insula; dACC, dorsal anterior cingulate cortex; ROI, region of interest.