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Effects of aromatic hydrophobic groups on antimicrobial activity
| Compd | MIC (µM) | HL50 (µM) |
CSI | HPLC Rt (min) |
|||
|---|---|---|---|---|---|---|---|
| S. aureus |
E. coli |
P. aeruginos a |
K. pneumoniae |
||||
| 3h | 25 | >50 | >50 | >50 | 600 | 24 | 10.643 |
| 3i | 3.1–6.2 | >50 | 25 | >50 | 150 | 24–48 | 11.491 |
| 3j | 3.1–6.2 | 12.5 | 25–50 | >50 | 40 | 12 | 11.924 |
| 3k | 6.2–12.5 | >50 | >50 | >50 | 300 | 24–48 | 10.973 |
| 3l | 3.1–6.2 | >50 | >50 | >50 | 150 | 24–48 | 11.159 |
| 6 | 12.5 | >50 | >50 | >50 | >600 | >48 | 10.537 |
