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A simulated mean oxygen and fluoromisonidazole (FMISO) uptake in 4-mm voxels (a–f) using a two-dimensional vessel map with varying vascularity, calculated by the methods described in Warren and Partridge.56 Red points indicate simulated blood vessel positions. Voxels (e) and (f) are predicted to show very similar binding, despite a large difference in PO2, due to the extent of necrosis in voxel (e).
