Fig. 6. The effect of racemic 1 and Δ-1 on the phosphorylation of MEK and ERK and expression of caspase 3, 6, and 9 in a kidney cancer xenograft model. Mice harboring A498 (human kidney cancer) tumors were injected with vehicle or with 1 or Δ-1 (14 mg kg–1) four times a week. (a) Racemic 1 and its enantiomer Δ-1 inhibit the phosphorylation of MEK and ERK. (b) Racemic 1 and its enantiomer Δ-1 induce caspase 3, 6, and 9 expression.
