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. 2017 Aug 28;114(37):E7660–E7669. doi: 10.1073/pnas.1704858114

Fig. 9.

Fig. 9.

Phosphorus dendrimers show antiinflammatory effects on LPS-stimulated monocytes-derived human macrophages. G3bis- and G4bis-phosphodendrimers (10 µM) inhibited LPS (100 ng/mL)-mediated increase in (A) CD86 and (B) iNOS expression; NFkB translocation from (C) cytosol to (D) the nucleus and (E) LPS (100 ng/mL)-mediated increase in nitrite production in monocytes-derived human macrophages. V represents cells treated with culture medium containing 10/00 DMSO. Western blot images show one experiment that was repeated three times with similar results. Graphs represent the ratio between optical densities of the indicated proteins after densitometric analysis of the Western blot experiments. Data are expressed as mean ± SEM from three experiments (AD) and from 6 to12 determinations from at least three different cell cultures (E). Background for β-actin gel in C was homogeneously reduced. *P < 0.05; **P < 0.01; ***P < 0.001, compared with LPS-treated cells.