Fig. S4.

Phosphorus dendrimers show antiinflammatory actions in the zymosan-injected air pouch model of subchronic inflammation. G3bis- and G4bis-phosphorus dendrimers (10 µM) injected into the air pouch: (A) reduced cell infiltration into the mouse air pouch, (B) diminished nitrite production, (C) inhibited iNOS expression in the cells migrated into the pouch in response to zymosan, and (D) reduced zymosan-induced iNOS and CD86 expression in the cells surrounding the cavity while preventing zymosan-mediated decrease in CD163. Western blot images show one experiment that was repeated three times with similar results. Data in A and B represent mean ± SEM from four animals. ***P < 0.001 compared with zymosan-treated group.