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. 2017 Aug 28;114(37):E7717–E7726. doi: 10.1073/pnas.1706831114

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Fig. 2. — ¹⁴C labeled bulk histone reaction with c-JMJD5 and c-JMJD7. Each section is labeled both on top and bottom. (Top) Controls and enzymes used; (Bottom) ¹⁴C-labeled bulk histone generated with individual PRMT proteins. (A) The activities of c-JMJD5 on bulk histone treated with PRMT1, PRMT5, PRMT6, and PRMT7, respectively. (B) The activities of c-JMJD7 on bulk histone treated with PRMT1, PRMT5, PRMT6, and PRMT7, respectively. (C) The ¹⁴C-SAM and digested bulk histone. (D) The activities of c-JMJD5, c-JMJD5 with three point of mutations on –HD/E(X)_nH– metal chelating site (HDH → AAA), and c-JMJD5 in the presence of EDTA on bulk histone generated with PRMT1. Cntl, control; H2A, histone subunit 2A; H3, histone subunit H3; H4, histone subunit H4.