Table 1.

Summary of enrollment and clinical and laboratory evaluations per study period.

	Study perioda			Start years	Specimen
	First	Second	Third
Patient enrollment	+	+	+	1989	–
Clinical evaluationsb	+	+	+	1989	–
Videotaping and scoringc	+	+	+	1989	–
Laboratory testing
Routine cerebrospinal fluid (CSF) studies	+	+	+	1989	Fresh CSF
Paraneoplastic antibodies		+	+	1997	Frozen serum
Flow cytometry		+	+	2001	Fresh CSF and blood
Oligoclonal bands		+	+	2002	Frozen CSF and serum

^aThe three study periods were 1989–1997, 1997–2005, and 2005–2013.

^bHistory and videotaped neurological examination performed by child neurologist and child neurology-specialized nurse practitioner.

^cThe OMS video evaluation scale was published in 2001 (21).