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. 2017 Feb 20;4(1):185–200.e1. doi: 10.1016/j.jcmgh.2017.02.001

Figure 4.

Figure 4

Bcl-xL overexpression accelerates the incidence rate of PDAC and reduces survival time in P-KrasG12D mice. P-KrasG12D mice and Bcl-xL Tg P-KrasG12D mice were killed at the indicated months. (A) Western blot of anti-apoptotic Bcl-2 family proteins in the pancreas at 4 months. (B) Representative images of pancreas sections at 4 months stained for Bcl-xL. Scale bar: 100 μm (original magnification, ×400); width of insets: 50 μm. (C) Macroscopic pictures of the pancreas at 4 months. Arrows, macroscopically evident tumors. (D) Representative images of H&E staining of pancreas sections. Scale bar: 100 μm (original magnification for A–F, ×40; G–I, ×200). (E) The ratio of microscopic and macroscopic PDAC ∗P < .05. (F) The percentage of normal pancreas at 2 months (n = 12 per each), 4 months (n = 10 or 11), and 7 months (n = 6 per each). *P < .05. (G) The number of PanINs per defined area in the pancreas sections of P-KrasG12D mice and Bcl-xL Tg P-KrasG12D mice (n = 12 per group) at 2 months ∗P < .05. (H) Kaplan–Meier survival analysis of P-KrasG12D (n = 11) and Bcl-xL Tg P-KrasG12D mice (n = 12). *P < .05.