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. 2017 Feb 20;4(1):185–200.e1. doi: 10.1016/j.jcmgh.2017.02.001

Figure 5.

Figure 5

Bcl-xL overexpression suppresses oncogene-induced senescence in low-grade PanINs and apoptosis in high-grade PanINs. (A and B) Pancreatic tissues of P-KrasG12D mice at 12–14 months and Bcl-xL Tg P-KrasG12D mice at 2 months were stained with H&E and TUNEL (n = 5 per group). (A) Representative images of H&E and TUNEL staining and (B) the percentage of TUNEL-positive cells. Scale bar: 100 μm (original magnification, ×400). (C–E) Pancreatic tissues of P-KrasG12D mice at 12–14 months and Bcl-xL Tg P-KrasG12D mice at 2 months were stained for SA–β-gal activity and stained with anti-p21 antibody (n = 5 per group). (C) Representative images of staining for SA–β-gal activity. Scale bar: 100 μm (original magnification, ×400). (D) Representative images of p21 staining of pancreas sections and (E) the percentage of p21-positive cells. Scale bar: 100 μm (original magnification, ×400). *P < .05.