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. 2017 Feb 20;4(1):185–200.e1. doi: 10.1016/j.jcmgh.2017.02.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Pancreas-specific Bcl-xL–knockout mice do not show any phenotype under physiological conditions. Bcl-xL KO mice (bcl-x^flox/floxPdx1-Cre) and their control littermates (bcl-x^flox/flox) were killed at the indicated months. (A) Western blot analysis of Bcl-xL in the pancreas at 2 months. (B) Representative images of H&E staining of pancreas sections at 6 months. Scale bar: 100 μm (original magnification, ×200). (C) Pancreas/body weight ratio and serum amylase and lipase levels at 6 months (n = 11 in Bcl-xL KO mice and n = 7 in control mice).