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. 2017 Feb 20;4(1):185–200.e1. doi: 10.1016/j.jcmgh.2017.02.001

Figure 7.

Figure 7

Bcl-xL deficiency increases senescence in high-grade PanINs. Bcl-xL KO P-KrasG12D mice (bcl-xflox/floxPdx1-Cre LSL-KrasG12D) (n = 14) and their littermate P-KrasG12D mice (bcl-x+/+Pdx1-Cre LSL-KrasG12D) (n = 6) were killed at 12 months. (A) Western blot of Bcl-xL in the pancreas. (B) Representative images of pancreas sections stained for Bcl-xL. Scale bar: 100 μm (original magnification, ×200). (C) Representative images of staining for SA–β-gal activity. Scale bar: 100 μm (original magnification, ×400). (D) Representative images of p21 staining in pancreas sections and (E) the percentage of p21-positive cells. Scale bar: 50 μm (original magnification, ×1200). *P < .05. (F) Representative images of H&E and TUNEL staining and (G) the percentage of TUNEL-positive cells. Scale bar: 100 μm (original magnification, ×400).