Table 2.
The associations of HBV infection with the risk of NK/T cell lymphoma.
| Cases (N=417) |
Controls (N=488) |
Univariable | Multivariable | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | No. | % | No. | % | OR | 95%CI | p | AOR* | 95%CI | p | |
| HBV markers | |||||||||||
| HBsAg(-) | 367 | 88.01 | 432 | 88.5 | 1(reference) | 1(reference) | |||||
| HBsAg(+) | 50 | 11.99 | 56 | 11.5 | 1.051 | 0.700-1.577 | 0.810 | 1.004 | 0.662-1.525 | 0.984 | |
| Anti-HBs(-) | 166 | 39.81 | 187 | 38.3 | 1(reference) | 1(reference) | |||||
| Anti-HBs(+) | 251 | 60.19 | 301 | 61.7 | 0.939 | 0.719-1.228 | 0.647 | 0.936 | 0.712-1.231 | 0.637 | |
| HBeAg(-) | 406 | 97.36 | 476 | 97.7 | 1(reference) | 1(reference) | |||||
| HBeAg(+) | 11 | 2.64 | 11 | 2.3 | 1.172 | 0.503-2.733 | 0.713 | 1.096 | 0.457-2.628 | 0.838 | |
| Anti-HBe(-) | 288 | 69.06 | 365 | 74.8 | 1(reference) | 1(reference) | |||||
| Anti-HBe(+) | 129 | 30.93 | 123 | 25.2 | 1.329 | 0.993-1.779 | 0.056 | 1.343 | 0.998-1.809 | 0.052 | |
| Anti-HBc(-) | 243 | 58.27 | 320 | 65.6 | 1(reference) | 1(reference) | |||||
| Anti-HBc(+) | 174 | 41.73 | 168 | 34.4 | 1.364 | 1.041-1.786 | 0.024 | 1.352 | 1.025-1.782 | 0.033 | |
| HBV infection status | |||||||||||
| HBsAg-(-)/anti-HBc-(-)† | 241 | 58.1 | 320 | 65.6 | 1(reference) | 1(reference) | |||||
| HBsAg-(+)/anti-HBc-(+)‡ | 48 | 11.6 | 56 | 11.5 | 1.138 | 0.748-1.733 | 0.546 | 1.092 | 0.708-1.683 | 0.690 | |
| HBsAg-(-)/anti-HBc-(+)§ | 126 | 30.4 | 112 | 23.0 | 1.494 | 1.102-2.026 | 0.010 | 1.497 | 1.098-2.042 | 0.011 | |
| Immune response for HBV | |||||||||||
| anti-HBs-(+)/anti-HBc-(-)¶ | 147 | 35.3 | 216 | 44.3 | 1(reference) | 1(reference) | |||||
| anti-HBs-(+)/anti-HBc-(+)# | 104 | 24.9 | 85 | 17.4 | 1.798 | 1.261-2.564 | 0.001 | 1.880 | 1.308-2.701 | 0.001 | |
| anti-HBs-(-)/anti-HBc-(+)& | 70 | 16.8 | 82 | 16.8 | 1.254 | 0.856-1.837 | 0.244 | 1.213 | 0.815-1.804 | 0.341 | |
| anti-HBs-(-)/anti-HBc-(-) | 96 | 23.0 | 105 | 21.5 | 1.343 | 0.949-1.901 | 0.096 | 1.436 | 1.006-2.050 | 0.047 | |
The AOR* was adjusted by sex, age (as a continuous variable), ABO blood type, smoking status, alcohol drinking and a family history of cancers.
Abbreviations: OR, odds ratio; AOR, adjusted odds ratio; 95% CI, 95% confidence interval. HBsAg, hepatitis B surface antigen; anti-HBs, hepatitis B surface antibody; HBeAg, hepatitis B e antigen; anti-HBeAb, hepatitis B e antibody; anti-HBc, hepatitis B core antibody.
† Never infected with HBV; ‡ Chronic carrier of HBV; § Previously infected with HBV (resolved hepatitis B); ¶ Immune via vaccine; # Naturally immune to HBV infection; & Lack of immue response to HBV infection.