Table 4.
Summary of microarray studies on lncRNA related to PDAC.
| Author | Country | Publish year | Data source | Sample size in microarray | Differently expressed lncRNAs and mRNAs | Candidate lncRNAs and related mRNA | Utility |
|---|---|---|---|---|---|---|---|
| Tahira et al. | Brasil | 2011 | Sptted custom-cDNA microarray | 9 non-pancreatic tissue, 15 primary pancreatic adenocarcinoma, 6 metastases from primary panceatic tumors and 8 chronic pancreatitis | 1267 protein-coding mRNAs and 340 putative noncoding RNAs | PPP3CB, MAP3K14 and DAPK1 | Correlate in PDAC or metastasis |
| Li et al. | China | 2014 | LncRNA expression microarray | 3 pairs of PDAC patients | 3220 upregulated and 945 downregulated lncRNAs | lncRNA BC008363 | Independent prognostic factor |
| Ye et al. | China | 2014 | GSE30134 expression profiles | 18 pancreatic cancers and 9 normal pancreas | 21 lncRNAs | - | - |
| Li et al. | China | 2015 | Arraystar human lncRNA microarrays, V2 | 12 samples | 27 upregulated lncRNAs | HOTTIP | Promote cell proliferation, invasion, and chemoresistance |
| Wang et al. | China | 2015 | Agilent Array platform | PanIN cell line and PDAC cell line | 319 upregulated lncRNAs and 571 downregulated lncRNAs | 8 lncRNAs and 5 protein-coding genes | Wnt Pathway-Associated |
| Wang et al. | China | 2015 | Arraystar Human LncRNA Microarray, V3 | 12 samples | 36 upregulated and 78 downregulated lncRNAs | HOTTIP-005 and RP11-567G11.1 | prognostic and Diagnostic biomarker |
| Ye et al. | China | 2015 | Arraystar Human LncRNA Microarray, V3 | 12 samples | 3534 upregulated lncRNAs and 4751 downregulated lncRNAs | AFAP1-AS1 | Poor survival and short-term recurrence |
| fu et al. | China | 2016 | Affymetrix GeneChip Human Genome HG-U133 Plus 2.0 array | 84 samples | 20 upregulated and 15 downregulated lncRNAs | AFAP1-AS1, UCA1 and ENSG00000218510 | Diagnostic biomarker |
| hu et al. | China | 2016 | LncRNA Human Gene Expression Microarray V4.0 | PANC-1 cells treated with or without fenofibrate | 549 upregulated lncRNAs and 852 down regulated lncRNAs | LncRNA MEG3 | Promote pancreatic cancer cells proliferation |
| Li et al. | China | 2016 | Agilent Gene Expression Analysis | 6 samples | - | lncRNA-NUTF2P3-001 | Derepress the miR-3923/KRAS pathway |