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. Author manuscript; available in PMC: 2018 Feb 9.
Published in final edited form as: Chem Rev. 2017 Jul 21;117(15):10474–10501. doi: 10.1021/acs.chemrev.7b00117

Figure 9. Surface representation of MmARD showing residues likely involved in conformational gating.

Figure 9

KMTB, Phe149 and Trp155 are shown in stick representation, Ni is shown as a green sphere and the water molecules shown as red spheres. Trp155 resides in the loop region preceding the long C-terminal helix, and may be involved in conformational changes upon substrate binding. Phe149 may be involved in the assisting Trp155 in conformational gating. a) Overall structure, b) Overall structure showing the C-terminal helix and the loop preceding it in a cartoon representation, c) Active site structure showing Trp155, d) Active site structure showing Trp155 & Phe149.