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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Transl Stroke Res. 2017 Jan 19;8(4):374–385. doi: 10.1007/s12975-017-0520-z

Fig. 6.

Fig. 6

MiR-126 regulates cardiomyocyte MCP-1 and VCAM-1 expression as well as regulates cardiomyocyte hypertrophy in primary cultured cardiomyocyte cell: a Sarcomeric a-actinin (a cardiomyocyte maker) shows that more than 95% cultured cells are cardiomyocyte. b MiR-126 expression in scrambled and miR-126 knockdown cardiomyocyte. c MCP-1, VCAM-1 and TGF-β, and NOX2 gene expression measured by real-time PCR. d Cardiomyocyte surface area measurements. Knockdown of miR-126 expression in cardiomyocyte increases cardiomyocyte size. e MiR-126EC−/− EC-Exo significantly decreases miR-126 expression compared to miR-126fl/fl-EC-Exo. f, g MiR-126fl/fl-EC-Exo treatment decreases, but miR-126EC−/−EC-Exo treatment fails to decrease cardiomyocyte hypertrophy compared to non-treatment control