Table 2.
Annual resource use and benefit
| Itema | Annual cost (U.S. dollars) | Minimum –Maximum or α/β | Distribution |
|---|---|---|---|
| Cost of investment in quality | |||
| 1. Cost of trainings | |||
| Cost of training on product development | 8206 | 7620–9792 | Triangular |
| Cost of attending Joint UNICEF, UNFPA & WHO meeting with manufacturers and suppliers of diagnostic products, vaccines, finished pharmaceutical products and active pharmaceutical ingredients | 6040 | 3020–9060 | Triangular |
| Cost of attending local conference on WHO GMP | 12 | 1/12 | Gamma |
| Cost of internal GMP training | 23,116 | 1/23,116 | Gamma |
| Cost of PMG-MAN/NAFDAC training | 8040 | 1/8040 | Gamma |
| Cost of other external trainings (WAHO, WAPMAM, Cepat) | 3157 | 1/3157 | Gamma |
| 2. Cost of analyses | |||
| Cost of extra analysis in Nigeria | 118 | 1/118 | Gamma |
| Cost of extra analysis in Abroad | 412 | 1/412 | Gamma |
| 3. Engagement of consultants | |||
| Cost for calibration, validation of HVAC and qualification | 45,226 | 41,608–52,613 | Triangular |
| 4. Staff recruitment | |||
| Cost of employing eight staff including GMP trainer | 125,000 | 96,016–112,500 | Triangular |
| 5. Financial records | |||
| Cost of auditing international supplier | 2352 | 1/2352 | Gamma |
| Cost of auditing Nigeria supplier | 450 | 1/450 | Gamma |
| 6. Preventive maintenance | |||
| Maintenance cost (including spares, cost of hiring contractor) | 15,285 | 7642–15,285 | Triangular |
| 7. Product development | |||
| Cost of product development | 14,654 | 1/14,654 | Gamma |
| Cost of stability chamber | 6551 | 5459–8734 | Triangular |
| Design of palatability study | 821 | 586–1172 | Triangular |
| Palatability and adherence study | 4689 | 1/4689 | Gamma |
| Honorarium for key staff | 352 | 1/352 | Gamma |
| Time in analysis | 5862 | 1/5862 | Gamma |
| Cost of courier services | 293 | 1/293 | Gamma |
| 8. Facility upgrades or new buildings/structures | |||
| Equipment cost (HVAC, automated compression machine, blistering machine, HPLC, customized flame photometer, etc.) | 92,801 | 83,521–102,081 | Triangular |
| Cost of new building/upgrade (factory, laboratory) | 357,135 | 321,421–357,135 | Triangular |
| Cost of power generation | 331,658 | 1/331,658 | Gamma |
| Cost of change of filter | 7642 | 1/7642 | Gamma |
| Cost of change to more efficient blistering machine | 38,212 | 1/38,212 | Gamma |
| Cost of change to more efficient HPLC and Flame photometer | 43,671 | 1/43,671 | Gamma |
| Total | 1,141,753 | ||
| Benefit of Quality Improvement | |||
| Revenue from sales of zinc sulfate 20-mg dispersible tablets in 2016 | 6,500,000 | 1/6,500,000 | Gamma |
| Total | 6,500,000 | ||
aAll cost were annuitized or expressed as annual cost