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. 2017 Sep 18;15:34. doi: 10.1186/s12964-017-0189-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — OGN downregulates NF2. NF2 a mRNA and b protein expression are reduced in OGN-expressing cells, compared to control meningioma cells on qPCR and Western blot analysis, respectively. c Control cells demonstrate more NF2 immunoreactivity compared to OGN cells. *p < 0.05, scale bar 50 μm d Correlation analysis of human meningioma RNA microarray data displays significantly negative correlation of NF2 mRNA to OGN mRNA. e Analysis of human meningiomas reveals increased frequency of NF2 or chr22 loss in samples with higher OGN mRNA expression. f Western blotting analysis of OGN and NF2 protein expression in human meningiomas with intact (WT, wildtype) NF2 or NF2 loss in WHO grade 1 and 2 meningiomas. g Densitometry quantification displays NF2 loss tumors express low NF2 but higher OGN protein