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. Author manuscript; available in PMC: 2017 Sep 19.
Published in final edited form as: Chem Commun (Camb). 2013 May 14;49(50):5621–5629. doi: 10.1039/c3cc42236d

Scheme 4.

Scheme 4

[11C-carbonyl]Carbamates can be synthesized by nucleophilic alkylation of the trapped [11C]CO2 followed by amine substitution (left), or through activation of an intermediate carbamate salt using POCl3 (right). DBU: 1,8-Diazabicyclo[5.4.0]undec-7-ene; Q: fixation base; R: H, phenyl, vinyl, alkyl; X: Cl, Br, I, OTs, sulfate; asterisk denotes 11C.