[11C-carbonyl]Carbamates can be synthesized by nucleophilic alkylation of the trapped [11C]CO2 followed by amine substitution (left), or through activation of an intermediate carbamate salt using POCl3 (right). DBU: 1,8-Diazabicyclo[5.4.0]undec-7-ene; Q: fixation base; R: H, phenyl, vinyl, alkyl; X: Cl, Br, I, OTs, sulfate; asterisk denotes 11C.