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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Eur J Neurosci. 2016 Sep 11;45(1):167–174. doi: 10.1111/ejn.13376

Figure 5.

Figure 5

Dose-dependent effects of cocaine in mice trained to discriminate cocaine from saline when cocaine was administered alone or in combination with several doses of modafinil. Each point represents the mean of six subjects with SEM represented by the error bars. Abscissae: Dose of cocaine in mg/kg. Top panel ordinates: Percentage of responses on the cocaine-appropriate lever. Bottom panel ordinates: Rates of responding as a percentage of vehicle control rates. Note that modafinil significantly shifted the discriminative-stimulus effects of cocaine to the left (top panel). Modafinil did not modify the overall rate of responding even at doses in which it enhanced the subjective effects of cocaine (bottom panel).