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. 2017 Sep 19;5:71. doi: 10.1186/s40425-017-0277-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — CD8 staining in samples from CRC patients (IT injection versus IV infusion). 1. Image IT-301-B3-7 (top panel), tumor section from a patient with CRC treated with enadenotucirev given by IT injection (cohort A): brown CD8 staining (× 10 magnification) can be clearly seen infiltrating the tumor cells. 2. Image IV-101-B4-7 (middle panel), tumor section from a patient with CRC treated with enadenotucirev given by IV infusion (cohort B): brown CD8 staining (× 10 magnification) infiltrating the tumor cells can be clearly seen. 3. Image IT-302-B3-7 (bottom panel), tumor section from a patient with CRC treated with enadenotucirev given by IT injection (cohort A): higher magnification (× 40) showing closer detail of CD8-stained cells, which appear pleomorphic, a hallmark of activated CD8⁺ T cells