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. 2017 Sep 18;12:69. doi: 10.1186/s13000-017-0658-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Error in immune cell counts caused by tumor mask transfer. Bland-Altman plots illustrating errors of immune cell subtypes inside and outside the tumor mask. (a-c) The difference of CD68+, CD8+ or CD4+ counts between transferred and ground truth tumor masks is plotted on the y-axis. The x-axis represents the mean cell count underneath transferred and manual masks. The red line indicates the mean error and blue lines the 95% confidence interval of the error. p-values were calculated by a one-sided t-test. Zero indicates perfect concordance in cell counts underneath both masks. (d-f) Same as (a-c) but for TIL numbers outside the tumor area. (g) Representative image of transferred versus ground truth tumor mask