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. 2017 Sep 18;12:66. doi: 10.1186/s13024-017-0210-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Loss of neuronal complexity in the Arctic model is rescued in the absence of C5aR1. The average number of branchings for a given distance from the soma (um) of each neuron by Sholl analysis using the NeuroLucida software within the CA1 area of 10 mo (a) and 7 mo (b) mice (5 neurons/ animal, 3 mice per genotype) +/− SEM. * p < .05 for Arctic vs Arctic/C5aR1KO by 2 way ANOVA followed by Tukey’s multiple comparison test. (c) The same data are plotted to compare the 7 and 10 mo branching in wild type (left), Arctic (middle) and Arctic/C5aR1KO (right) mice, *p < .02 by one way ANOVA