Table 3.

Changes in cardiorespiratory support and laboratory parameters preceding death among hospitalized infants with late-onset sepsis.

	Baseline Day −5 (n=650)		Change from Days −5 to −4 (n=660)			Change from Days −4 to −3 (n=665)			Change from Days −3 to −2 (n=671)			Change from Days −2 to −1 (n=677)			Change from Days −1 to 0a (n=679)
Cardiorespiratory Support	n	%	nb	Δ%	P	nb	Δ%	P	nb	Δ%	P	nb	Δ%	P	nb	Δ%	P
Mechanical ventilation	650	72	660	0	0.89	665	+2	0.38	671	+7	0.003	677	+11	<0.001	678	+5	<0.001
Percentage FiO2, mean	640	37	652	−1	0.22	653	+3	<0.001	661	+7	<0.001	667	+13	<0.001	674	+22	<0.001
Receipt of one or more vasopressors	650	16	660	−2	0.34	665	0	0.80	671	+8	<0.001	677	+17	<0.001	679	+2	0.54
Laboratory Parameters
Creatinine ≥1.3 mg/dL	240	18	258	+3	0.46	257	0	0.90	277	+6	0.08	329	+3	0.47	281	+11	0.01
ANC <1000 cells/μL	194	7	188	0	0.93	231	+2	0.55	315	+8	0.01	395	+5	0.07	321	+5	0.09
Platelet count <100,000/μL	257	30	250	+4	0.29	289	+5	0.20	368	+7	0.06	460	+18	<0.001	384	+6	0.06

Δ, change; FiO2, fraction of inspired oxygen; ANC, absolute neutrophil count.

P values estimated using chi square tests or Wilcoxon signed rank tests.

^aDay 0 corresponds to day of death.

^bn corresponds to the number of infants with available data on the second day in the time interval.