Table 2.
Differences in methylation index (MI) of the genes between cases and controls.
| Night work exposure | CLOCK | BMAL1 | CRY1 | PER1 | PER2 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (95 %CI) |
Pa | Estimate (95 %CI) | Pa | Estimate (95 %CI) | Pa | Estimate (95 %CI) | Pa | Estimate (95 %CI) | Pa | |
| Neverb | 0.10 (-0.05 - 0.24) | 0.187 | 0.03 (-0.12 - 0.18) | 0.724 | 0.18 (0.04 - 0.31) | 0.009 | 0.13 (-0.02 - 0.28) | 0.090 | 0.04 (-0.10 - 0.18) | 0.553 |
| Everc | 0.01 (-0.07 - 0.10) | 0.733 | 0.07 (-0.01 - 0.16) | 0.101 | 0.00 (-0.07 - 0.10) | 0.962 | 0.07 (-0.04 - 0.18) | 0.118 | 0.02 (-0.06 - 0.10) | 0.645 |
| Lowb | 0.04 (-0.21 - 0.29) | 0.747 | 0.06 (-0.2 - 0.32) | 0.660 | -0.08 (-0.30 - 0.15) | 0.502 | 0.04 (-0.19 - 0.27) | 0.739 | 0.18 (-0.06 - 0.42) | 0.136 |
| Mediumb | 0.18 (0.00 - 0.36) | 0.050 | 0.33 (0.14 - 0.52) | 0.001 | 0.17 (0.00 - 0.33) | 0.044 | 0.23 (0.05 - 0.41) | 0.013 | 0.14 (-0.04 - 0.31) | 0.117 |
| Highb | -0.04 (-0.14 - 0.06) | 0.433 | 0.01 (-0.1 - 0.11) | 0.923 | -0.02 (-0.12 - 0.07) | 0.611 | 0.05 (-0.07 - 0.17) | 0.433 | -0.04 (-0.14 - 0.06) | 0.386 |
aDifferences in MI between cases and controls for each shift variable were analyzed using a linear mixed model with a random intercept to take into account the repeated observations for the CpG sites. Controls were used as reference. Adjustment variables were selected based on the AIC criterion. Adjustments were made for b alcohol (BMAL1), familiar breast cancer (CRY1), years since cancer and alcohol (PER1); and for c alcohol (BMAL1), familiar breast cancer and alcohol (CRY1), years since cancer and alcohol (PER1).