Table 2.

The prognostic impacts of host-related biomarkers by Cox-proportional hazard regression analysis.

Variable	Unit	Univariate Analysis			Multivariate Analysis
		HR	95% HR CI	P-value	HR	95% HR CI	P-value
Clinicopathologic factors
Age	1	1.02	1.01-1.04	<0.001
Sex	Male/female	0.73	0.51-1.04	0.083
ECOG-PS	0-1/2	2.01	1.40-2.88	<0.001
Stage	IIIB/IV	1.12	0.59-2.14	0.734
Cell type	Non-squamous cell carcinoma/ squamous cell carcinoma	1.44	0.93-2.23	0.106
Host-related biomarkers
Hemoglobin (g/dL)	Men <13/≥13	0.69	0.48-0.99	0.046
	Women <12/≥12
Ferritin (ng/mL)	Men ≤200/>200	1.91	1.33-2.73	<0.001	1.81	1.24-2.64	0.002
	Women ≤150/>150
Platelet (×103/μL)	<400/≥400	1.49	0.80-2.78	0.212
Neutrophil (cells/μL)	≤7700/>7700	3.41	2.02-5.75	<0.001
Lymphocyte (cells/μL)	<1500/≥1500	0.63	0.44-0.90	0.011	0.57	0.40-0.83	0.004
Monocyte (cells/μL)	≤800/>800	4.40	2.37-8.16	<0.001	3.15	1.64-6.04	<0.001