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. 2017 Sep 2;8(15):3037–3048. doi: 10.7150/jca.19315

Figure 4.

Figure 4

MiR-340 suppressed tumor growth in an orthotopic breast cancer mouse model. (A) MDA-MB-231 subcutaneous tumors were treated with NC, miR-340 mimics and miR-340 inhibitor. Growth curves of tumor volumes in NC, mimics and inhibitor group (n=8 in each group). (B) Tumors were resected and tumor mass was determined 21 days following implantation. Data indicate decreased tumor mass miR-340 mimics-treated tumors compared with NC and miR-340-inhibitor treatment. (C) MiR-340, EZH2, Ki-67 and MMP9 expressions were detected by IHC and FISH. Data represent mean ± SD of three replicates. *P < 0.05.