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. 2017 Sep 2;8(15):3078–3085. doi: 10.7150/jca.20250

Figure 1.

Figure 1

Mean ADCs of MCF-7 breast cancer cells and 8932 pancreatic cancer cells (A) of lactate (except for necrotic cells, for which no lactate was detectable), pyruvate, fumarate and malate (detectable for necrotic cells only) and (B) necrotic 8932 pancreatic cancer cells which were treated with membrane permeabilizing Triton X-100 displaying that malate is only present in necrotic cells while at the same time no lactate metabolism is detectable. The bar represents the mean. (C) ADClac/ADCpyr ratio of MCF-7 breast cancer cells and 8932 pancreatic cancer cells relative to the amount of dead cells (%). Mean values of ADClac/ADCpyr between MCF-7 (0.533 ± 0.015) and 8932 cells (0.744 ± 0.064) showed a significant difference (p = 0.048). D displays sample spectra of MCF-7 cells, 8932 cells and necrotic 8932 cells.