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. 2017 Aug 22;12(9):2417–2426. doi: 10.1021/acschembio.7b00636

Figure 4.

Figure 4

Base pairs of OG with A or C and the impact an OG:A base pair has on transcription in WT- or Ogg1–/–-MEF cells when located in the VEGF PQS in a luciferase reporter gene. (A) Structures for the OG:C and OG:A base pairs. Expression observed in WT MEFs when OG is in either the coding (B) or template (C) strand base paired with A. Expression observed in Ogg1–/– MEFs when OG is in either the coding (D) or template (E) strand base paired with A. On the basis of a Student’s t test, the time in which significance at *P < 0.05, **P < 0.01, or ***P < 0.001 was first observed is marked on each plot.