Figure 1.

Forces on a protein group R_i. The Direct force ( ${\mathit{F}}_i^D$), due to the rest of the protein (R^M−i), and the indirect, Solvent-Induced force ( ${\mathit{F}}_i^{SI}$), due to a water molecule W are shown as solid arrows. The effect of the entire protein on the density of solvent at X_w is shown as dashed arrows.