Table 2.
Genotype and allele frequencies of three SNPs in CYP19A1 gene in the CRC patients and controls
| SNP | Variation | Case | Control | OR | CI | χ2 | P-value |
|---|---|---|---|---|---|---|---|
| rs4774585 | GG | 46 (46) | 48 (48) | Ref | |||
| AG | 46 (46) | 41 (41) | 1.17 | 0.65–2.09 | 0.28 | 0.59 | |
| AA | 8 (8) | 11 (11) | 0.76 | 0.28–2.05 | 0.30 | 0.58 | |
| AG + AA | 54 (54) | 52 (52) | 1.08 | 0.62–1.88 | 0.08 | 0.77 | |
| G | 138 (69) | 137 (68.5) | Ref | ||||
| A | 62 (31) | 63 (31.5) | 0.977 | 0.64–1.49 | 0.01 | 0.91 | |
| rs936308 | GG | 5 (5) | 9 (9) | Ref | |||
| CG | 35 (35) | 34 (34) | 0.97 | 0.53–1.77 | 0.01 | 0.94 | |
| CC | 60 (60) | 57 (57) | 1.89 | 0.59–5.99 | 1.21 | 0.27 | |
| CG + GG | 40 (40) | 43 (43) | 0.88 | 0.50–1.55 | 0.19 | 0.66 | |
| G | 45 (22.5) | 52 (26) | Ref | ||||
| C | 155 (77.5) | 148 (74) | 1.21 | 0.76–1.91 | 0.67 | 0.41 | |
| rs4775936 | CC | 37 (37) | 35 (35) | Ref | |||
| CT | 44 (44) | 47 (47) | 0.88 | 0.47–1.60 | 0.15 | 0.70 | |
| TT | 19 (19) | 18 (18) | 0.99 | 0.45–2.20 | 0.00 | 0.99 | |
| CT + TT | 63 (63) | 65 (65) | 0.91 | 0.51–1.63 | 0.09 | 0.76 | |
| C | 118 (59) | 117 (58.5) | Ref | ||||
| T | 82 (41) | 83 (41.5) | 0.98 | 0.65–1.45 | 0.01 | 0.92 |
Abbreviations: CRC, colorectal cancer; OR, odds ratio; Ref, reference; SNP, single nucleotide polymorphism; CI, confidence interval.