. 2017 Sep 14;10:4559–4567. doi: 10.2147/OTT.S121557

Table 3.

Comparison of the genotype and allele frequencies of three SNPs in CYP19A1 gene in the colon and rectum cancer patients and the control group

SNP	Variation	Case^a		Control	Colon vs rectal				CRC vs control
SNP	Variation	Colon	Rectal	Control	OR	CI	χ²	P-value	OR	CI	χ²	P-value
rs4774585	GG	46 (70.7)	–	48 (48)	Ref				Ref
		–	15 (45.4)
	AG	11 (16.9)	–	41 (41)	4.46	1.70–11.6	9.86	0.001	1.05	0.54–2.04	0.03	0.86
		–	16 (48.4)						1.24	0.55–2.83	0.28	0.59
	AA	8 (14)	–	11 (11)	0.76	0.14–4.01	0.10	0.75	0.84	0.28–2.51	0.09	0.76
		–	2 (6.06)						0.58	0.11–2.92	0.44	0.50
	AG + AA	19 (29.2)	–	52 (52)	2.90	1.21–6.92	5.97	0.014	1.21	0.42–3.46	0.13	0.71
		–	18 (54.5)						1.10	0.50–2.44	0.06	0.78
	G	103 (56.9)		137 (68.5)	Ref				Ref
			46 (69.6)
	A	27 (18.46)		63 (31.5)	1.65	0.84–3.25	2.18	0.13	0.966	0.60–1.55	0.02	0.88
			20 (30.3)						0.94	0.51–1.72	0.03	0.855
rs936308	GG	4 (0.06)		9 (9)	Ref				Ref
			1 (3.03)
	CG	22 (33.8)		34 (34)	3.81	0.39–37.0	1.50	0.22	0.94	0.48–1.85	0.03	0.87
			21 (63.6)						3.201	1.37–7.44	7.65	0.005
	CC	38 (58.4)		57 (57)	1.15	0.11–11.4	0.02	0.90	1.53	0.44–5.35	0.47	0.49
			11 (33.3)						1.73	0.19–15.12	0.26	0.61
	CG + GG	27 (41.5)		43 (43)	1.15	0.11–11.4	0.02	0.90	1.50	0.44–5.11	0.44	0.50
			22 (66.6)						2.65	1.16–6.04	5.56	0.01
	G	30 (23.0)		52 (26)	Ref				Ref
			23 (34.8)
	C	98 (75.3)		148 (74)	0.57	0.29–1.09	2.86	0.09	1.17	0.69–1.96	0.36	0.54
			43 (65.1)						0.65	0.36–1.19	1.92	0.16
rs4775936	CC	31 (47.6)		35 (35)	Ref				Ref
			16 (48.4)
	CT	22 (33.8)		47 (47)	0.96	0.37–2.48	0.00	0.94	0.88	0.47–1.60	0.15	0.70
			11 (33.3)						0.51	0.21–1.23	2.24	0.13
	TT	12 (18.4)		18 (18)	0.96	0.30–3.06	0.00	0.95	0.99	0.45–2.20	0.00	0.99
			6 (18.1)						0.72	0.24–2.18	0.32	0.57
	CT + TT	34 (52.3)		65 (65)	0.96	0.41–2.24	0.01	0.94	0.91	0.51–1.63	0.09	0.76
			17 (51)						0.57	0.25–1.26	1.91	0.16
	C	84 (64.6)		117 (58.5)	Ref				Ref
			43 (65.1)
	T	46 (35.3)		83 (41.5)	0.97	0.52–1.81	0.01	0.94	0.77	0.48–1.21	1.24	0.26
			23 (34.8)						0.75	0.42–1.34	0.92	0.33

Note:

The total number of patients is not 100, since the location was not available for a few patients.

Abbreviations: CRC, colorectal cancer; OR, odds ratio; Ref, reference; SNP, single nuclear polymorphism; CI, confidence interval.