Table 4.
Genotype and allele frequencies of three SNPs in CYP19A1 gene in females and males colorectal cancer patients and the control group
| SNP | Variation | Casea | Control | OR | CI | χ2 | P-value |
|---|---|---|---|---|---|---|---|
| rs4774585 | Females | ||||||
| GG | 18 (42.85) | 29 (49.15) | Ref | ||||
| AG | 20 (47.61) | 12 (28.33) | 1.11 | 0.49–2.52 | 0.06 | 0.80 | |
| AA | 4 (9.52) | 1 (1.69) | 6.44 | 0.66–62.3 | 3.22 | 0.07 | |
| AG + AA | 24 (57.14) | 13 (22.03) | 1.28 | 0.58–2.85 | 0.39 | 0.53 | |
| G | 56 (66.66) | 70 (59.32) | Ref. | ||||
| A | 28 (33.33) | 14 (11.86) | 1.40 | 0.76–2.58 | 1.18 | 0.27 | |
| Males | |||||||
| GG | 27 (46.55) | 19 (46.34) | Ref | ||||
| AG | 26 (44.82) | 12 (29.26) | 1.52 | 0.61–3.75 | 0.85 | 0.35 | |
| AA | 4 (6.89) | 10 (24.39) | 0.28 | 0.07–1.03 | 3.90 | 0.04 | |
| AG + AA | 29 (50) | 22 (53.65) | 0.96 | 0.42–2.14 | 0.01 | 0.91 | |
| G | 80 (68.96) | 50 (60.97) | Ref | ||||
| A | 56 (48.27) | 32 (39.02) | 0.66 | 0.36–1.20 | 1.81 | 0.17 | |
| rs936308 | Females | ||||||
| GG | 3 (7.14) | 4 (6.77) | Ref | ||||
| CG | 11 (26.19) | 23 (38.98) | 0.54 | 0.22–1.31 | 1.83 | 0.17 | |
| CC | 28 (66.66) | 32 (54.23) | 1.16 | 0.24–5.66 | 0.04 | 0.84 | |
| CG + GG | 13 (30.95) | 27 (45.76) | 0.59 | 0.26–1.34 | 1.57 | 0.20 | |
| G | 17 (20.23) | 31 (26.27) | Ref | ||||
| C | 67 (79.76) | 69 (58.47) | 1.40 | 0.71–2.74 | 0.99 | 0.32 | |
| Males | |||||||
| GG | 3 (5.17) | 5 (12.19) | Ref | ||||
| CG | 23 (39.65) | 11 (26.82) | 1.63 | 0.67–3.97 | 1.18 | 0.27 | |
| CC | 32 (55.17) | 25 (60.97) | 2.13 | 0.46–9.79 | 0.98 | 0.32 | |
| CG + GG | 26 (44.82) | 22 (53.65) | 1.27 | 0.56–2.86 | 0.33 | 0.56 | |
| G | 29 (25.38) | 21 (25.60) | Ref | ||||
| C | 87 (75.61) | 61 (74.39) | 1.03 | 0.53–1.97 | 0.01 | 0.92 | |
| rs4775936 | Females | ||||||
| CC | 20 (47.61) | 17 (28.81) | Ref | ||||
| CT | 14 (33.33) | 32 (54.23) | 0.37 | 0.15–0.91 | 4.73 | 0.02 | |
| TT | 8 (19.04) | 10 (16.94) | 0.68 | 0.21–2.21 | 0.45 | 0.50 | |
| CT + TT | 22 (52.38) | 42 (71.18) | 0.44 | 0.19–1.01 | 3.74 | 0.05 | |
| C | 54 (64.28) | 66 (55.93) | Ref. | ||||
| T | 30 (35.71) | 52 (44.06) | 0.70 | 0.39–1.25 | 1.42 | 0.23 | |
| Males | |||||||
| CC | 18 (31.03) | 18 (43.9) | Ref | ||||
| CT | 29 (50) | 16 (39.02) | 1.81 | 0.74–4.43 | 1.71 | 0.19 | |
| TT | 11 (18.96) | 7 (17.07) | 1.57 | 0.49–4.96 | 0.60 | 0.44 | |
| CT + TT | 40 (68.96) | 23 (56.09) | 1.73 | 0.75–3.99 | 1.72 | 0.18 | |
| C | 65 (56.03) | 52 (63.41) | Ref | ||||
| T | 51 (43.96) | 30 (36.58) | 1.36 | 0.76–2.42 | 1.08 | 0.29 |
Note:
a
The total number of patients is not 100, since the gender was not recorded for a few patients.
Abbreviations: OR, odds ratio; Ref, reference; SNP, single nucleotide polymorphism; CI, confidence interval.