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. 2017 Jul 13;3(1):e000365. doi: 10.1136/rmdopen-2016-000365

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Frequency of neutrophils and RANKL neutrophils. (A) Neutrophil frequency is significantly higher in patients with RA at baseline when compared with healthy donors (both frequency p=0.0110 and absolute number p=0.0032). (B) RANKL+neutrophil count is also higher at baseline when compared with healthy donors (p=0.0060). Neutrophil number is decreased after MTX and low-dose prednisolone treatment in patients with RA (absolute number only, p=0.0155). Each dot represents a sample and the line in healthy represents median. RA, rheumatoid arthritis; MTX, methotrexate; RANKL, receptor activator of nuclear factor-κβ ligand.