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. 2017 Jul 13;3(1):e000365. doi: 10.1136/rmdopen-2016-000365

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Serum sRANKL and OPG levels in healthy donors and patients with RA at baseline and after MTX and low-dose prednisolone treatment. Both sRANKL and the sRANKL/OPG ratio increased in patients at baseline when compared with healthy donors. There were no differences in circulating OPG level before and after treatment or when compared with controls. The sRANKL/OPG ratio remained significantly higher after treatment. Each dot represents a sample and the line in healthy represents median. sRANKL, soluble receptor activator of nuclear factor-κB ligand; OPG, osteoprotegerin; RA, rheumatoid arthritis.