Table 3.

HR of death in patients with AAV across subgroups identified by cluster affiliation, multivariable Cox regression

	HR	LCL HR	UCL HR	p Value
Female	1			(reference)
Male (0–1.85 years)	1.89	0.92	3.90	0.084
Male (1.85–8.5 years)	0.84	0.46	1.55	0.582
Male (>8.5 years)	0.34	0.13	0.90	0.029
Age (1-year increase)	1.09	1.07	1.12	<0.001
Cluster A, non-renal	1			(reference)
Cluster B, renal with PR3	2.53	1.25	5.12	0.010
Cluster C, renal without PR3	2.70	1.34	5.46	0.005
Cluster D, cardiovascular	6.38	2.52	16.15	<0.001
Cluster E, gastrointestinal	3.98	1.52	10.39	0.005

Cluster affiliation for AAV (Mahr et al ⁸) with nine clinical variables and ANCA specificity.

AAV, ANCA-associated vasculitis; ANCA, antineutrophil cytoplasmatic antibody; LCL, lower confidence limit; PR3 proteinase 3; UCL; upper confidence limit.