Skip to main content
. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Lancet Neurol. 2017 Sep 12;16(10):837–847. doi: 10.1016/S1474-4422(17)30280-6

Figure 2.

Figure 2

First, second and third generation ASOs and native DNA. Each generation may contain numerous variations around the altered characteristic.43 HTTRx combines a phosphorothioate backbone (1st generation) with 2’-O-MOE modification (2nd generation) and is considered a 2nd generation ASO overall.26