Fig. 7.

Vaccine effectiveness for the prevention of tissue damage. Serum activity of cardiomyopathy-associated enzymes from immunized and infected mice. Creatinine kinase (CK), creatinine kinase MB isoform (CK-MB), lactate dehydrogenase (LDH, U/I ×10), and glutamate oxaloacetate transaminase (GOT) (a). Results are expressed as mean ± SEM. *p < 0.05, **p < 0.01, one-way-ANOVA Kruskal-Wallis test + Dunn’s multiple comparisons test. Histopathological analysis of T. cruzi-target organs during the chronic phase of infection. Representative tissue sections (H&E stained) for the indicated groups (b). Magnification level: 100×. Insets: 400×. Table shows Inflammation score semi-quantitatively evaluated for each group (-, absence of inflammation; number of crosses indicate degree of inflammation). Solid arrows point to mononuclear cell infiltrates. Dashed arrow points to a nerve associated with mononuclear cell infiltrates. Results are representative of two independent experiments