Table 1.
Clinicopathologic and operative characteristics of the cohort stratified by receipt of chemotherapy
| Total (n=876) | No Chemotherapy (n=713) | Chemotherapy (CTx) (n=163) | P-value | |
|---|---|---|---|---|
| Age, years, median (IQR) | 74 (63, 81.5) | 76 (66, 83) | 62 (53, 72) | <0.001 |
| Male sex | 422 (48.2) | 341 (47.8) | 81 (50.0) | 0.67 |
| Ethnicity | 0.78 | |||
| Caucasian | 705 (80.5) | 577 (80.9) | 128 (78.6) | |
| Black | 129 (14.7) | 104 (14.6) | 25 (15.3) | |
| Asian | 24 (2.7) | 16 (2.2) | 8 (4.9) | |
| Location of Tumor | 0.66 | |||
| Ascending Colon | 474 (54.1) | 393 (55.1) | 81 (49.7) | |
| Transverse Colon | 100 (11.4) | 80 (11.2) | 20 (12.3) | |
| Descending Colon | 57 (6.5) | 45 (6.3) | 12 (7.4) | |
| Rectosigmoid Colon | 245 (28.0) | 195 (27.4) | 50 (30.7) | |
| Year of Surgery | 0.01 | |||
| Before 2010 | 530 (60.5) | 417 (58.5) | 113 (69.3) | |
| After 2010 | 346 (39.5) | 296 (41.5) | 50 (30.7) | |
| Stage | <0.001 | |||
| IIA | 744 (84.9) | 623 (87.4) | 121 (74.2) | |
| IIB | 116 (13.2) | 80 (11.2) | 36 (22.1) | |
| IIC | 16 (1.8) | 10 (1.4) | 6 (3.7) | |
| Lymph nodes examined (IQR) | 17 (13, 23) | 16 (13, 22) | 18 (14, 26) | 0.002 |
| Margins | 0.002 | |||
| R0 | 843 (96.2) | 693 (97.2) | 150 (92.0) | |
| R1 | 33 (3.8) | 20 (2.8) | 13 (8.0) | |
| Lymphovascular Invasion (N=317) | 53 (16.7) | 42 (15.4) | 11 (24.2) | 0.13 |
| Perineural Invasion (N=312) | 12 (3.9) | 6 (2.3) | 6 (13.3) | <0.001 |
| Microsatellite Stability (N=347) | 281 (81.2) | 245 (82.8) | 36 (72.0) | 0.07 |