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. Author manuscript; available in PMC: 2018 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2017 Mar 15;86:225–244. doi: 10.1146/annurev-biochem-061516-044820

Figure 1. The autophagy program.

Figure 1

(A) Preautophagosome assembly site (PAS). (B) PAS elongates into phagophore to surround bulk cytosolic materials. (C) The geometry of phagophore closure. (D) The closed autophagosome. (E) The autophagosome merges with the lysosome; the new organelle is the autolysosome.