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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Immunity. 2017 Apr 18;46(4):562–576. doi: 10.1016/j.immuni.2017.04.008

Figure 3. Commensal colonization differentially regulates innate and innate-like lymphoid cells.

Figure 3

(1) Microbe-derived riboflavin metabolites promote development of mucosal-associated invariant T (MAIT) cells.

(2) Commensal-induced cytokines IL-1β and IL-23 promote IL-17A production from γδT cells.

(3) ILC3-derived IL-22 prevents translocation of Alcaligenes spp. to lymphoid architecture and promotes epithelial cell production of serum amyloid A (SAA)1/2 to license IL-17A production from Th17 cells.

(4) ILC3-expressing MHC-II delete activated commensal-specific CD4+ T cells.

(5) Early life colonization limits iNKT expansion and pathogenic function within the colonic lamina propria and lungs.